Have You Heard the Rumor About PDRN Being Derived from Salmon Sperm? It may sound like an urban legend, but the truth is a bit more complex. Let’s dive into the facts!
PDRN (polydeoxyribonucleotide) is a powerful skincare ingredient that has taken the K-Beauty world by storm. This biotechnologically derived component, extracted from salmon DNA, is known for its rejuvenating and reparative properties. Whether you're looking to reduce wrinkles, hydrate your skin, or soothe irritation—PDRN is an ingredient worth knowing about!
What is PDRN and how does it work?
PDRN consists of DNA fragments that have been shown to stimulate skin cell renewal and tissue repair. By activating fibroblasts—the skin cells responsible for collagen production—PDRN helps maintain skin elasticity and firmness. This makes it an excellent ingredient for combating fine lines and loss of skin resilience.

Advantages of PDRN in skincare:
Anti-aging effect – Stimulates collagen production and reduces wrinkles.
Soothing & repairing – Perfect for irritated and sensitive skin.
Moisturizing – Helps to maintain the skin's moisture balance.
Faster healing – PDRN is often used in aesthetic treatments to promote the skin's recovery process.
The extraction process and vegan alternative
Traditionally, PDRN is extracted from salmon or other fish DNA through a biotechnological process where DNA fragments are isolated and purified for use in skincare. Many believe that PDRN comes from salmon sperm, and that’s not entirely wrong—one of the richest sources of DNA in salmon is, in fact, its milt (sperm). Through advanced technology, DNA structures are separated from other substances and purified to create a safe and effective skincare ingredient.
However, there are also vegan alternatives to PDRN, where the ingredient is synthesized biotechnologically without any animal-derived components. These versions mimic the natural properties of PDRN and can provide similar benefits for skin repair and anti-aging, making them an excellent choice for those who prefer vegan skincare.

PDRN in K-Beauty
In Korean skin care, PDRN is found in everything from serums, essences, creams, to sheet masks. It is a popular ingredient in products aimed at aging, dry, and sensitive skin, but it is also suitable for those who want to prevent early signs of aging.
Popular PDRN products at Yeppo:
Anua PDRN Hyaluronic Acid Capsule 100 Serum – A fresh serum combining PDRN and hyaluronic acid to maximize skin hydration and repair. Perfect for dry and sensitive skin needing extra water moisture!
- Dr.Reju-All Advanced PDRN Rejuvenating Cream is one of Korea’s most esteemed PDRN products. Dr.Reju-All is the top brand in Korean pharmacies, and their carefully formulated products have gained huge popularity worldwide.
- Genabelle PDRN Vita Toning Ampoule is a popular and beginner-friendly PDRN serum in Korea, especially suitable for dull skin. PDRN and peptides deeply moisturize and smooth the skin, while antioxidants bring brightness and glow.
VT Cosmetics PDRN Essence 100 – A concentrated essence-serum for intensive skin rejuvenation, increasing elasticity and moisture. Ideal for strengthening the skin’s protective barrier and adding radiance! Contains vegan PDRN.
Heveblue Salmon Caring line – A complete skin care line enriched with PDRN for maximum skin repair and glow.
Heveblue Cleansing Foam – An easy way to include PDRN in your daily skin care routine.

How to use PDRN in your skin care routine?
PDRN is most commonly found in serum form, which should be applied after cleansing and toner to absorb optimally. Combine it with other moisturizing and skin barrier-strengthening ingredients, such as hyaluronic acid and ceramides, for the best possible result.
Whether you are just getting to know PDRN or want to expand your skin care routine, this powerful ingredient is definitely worth trying for its incredible skin renewing effects!

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